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Amitriptyline preserves morphines antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats

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In addition, TMT exposure can trigger neuroinflammatory responses, characterized by increased levels of pro-inflammatory cytokines such as TNF-, IL-1, and nitric oxide, and increased gene expression of the glial fibrillary acidic protein and activated microglia in the brain

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